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Biochem J 306:565569 Mithen R, Faulkner K, Magrath R et al (2003) Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells

Graf and Kastin proposed in their 1984 review that DSIP exerts programming rather than acute pharmacological effects a framing that captures the reproducibility difficulties of the literature

Chronic studies: Require lower daily doses over an extended period to observe long-term effects, necessitating careful consideration of potential cumulative effects or receptor desensitization

Denaturation is sort of a natural part of life for a protein and is somewhat unavoidable